Children's Literature
In this subdiscipline:
9,120 papers
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Popular papers
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Synapse loss is strongly correlated with cognitive impairment in Alzheimer's disease (AD). We have previously reported the loss of dendritic spines and the presence of dystrophic neurites in both the hippocampi of transgenic mice overexpressing…
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In this article, we have characterized and compared gene expression profiles from laser capture microdissected neurons in six functionally and anatomically distinct regions from clinically and histopathologically normal aged human brains. These…
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A 42-year-old woman presented with ptosis of the left upper lid and limitation of elevation and adduction of the left eye. Neuroimaging revealed a left cavernous sinus lesion which on biopsy proved to be a meningioma. She was symptomatically stable…
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Neurofibrillary tangles (NFT) constitute one of the cardinal histopathological features of Alzheimer's disease (AD). To explore in vivo molecular processes involved in the development of NFTs, we compared gene expression profiles of NFT-bearing…
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Alzheimer's Disease (AD) is the most widespread form of dementia during the later stages of life. If improved therapeutics are not developed, the prevalence of AD will drastically increase in the coming years as the world's population ages. By…
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PURPOSE OF REVIEW: To explore the role of iron physiology in the brain of healthy adults and review how increased brain iron deposition has been associated with common neurodegenerative diseases that affect the elderly. RECENT FINDINGS: Because iron…
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A number of beta-carbolines are inverse agonists of the GABA-A receptor complex, acting on the benzodiazepine site. They show convulsive properties when administered at high doses, anxiogenic properties at moderate doses, and learning-enhancing…
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The applicability of several theories of leisure motivation to a range of 36 activities typically undertaken by younger people has been investigated. The theories were Csikzentmihalyi's theory of ow (theory 1), Bandura's theory of self-ecacy (theory…
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Alzheimer's disease (AD) is characterized by deterioration in mental function leading to dementia, deposition of amyloid plaques and neurofibrillary tangles (NFTs), and neuronal loss. The major component of plaques is the amyloid-beta peptide (A…
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Background: Despite sharing the same genes, identical twins demonstrate substantial variability in behavioral traits and in their risk for disease. Epigenetic factorsDNA and chromatin modifications that affect levels of gene expression without…
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Understanding the changes in the brain which occur in the transition from normal to addictive behavior has major implications in public health. Here we postulate that while reward circuits (nucleus accumbens, amygdala), which have been central to…
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Neocortical neurons maintain high firing rates across all behavioral states of vigilance but the discharge patterns vary during different types of brain oscillations, which are assumed to play an important role in information processing and memory…
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Beta-Site amyloid precursor protein cleaving enzyme 1 (BACE1) initiates amyloid-beta (Abeta) generation that is central to the pathophysiology of Alzheimer's disease (AD). Therefore, lowering Abeta levels by BACE1 manipulations represents a key…
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A method of measuring magnetic dissipation on a sub-100 nm scale is presented. This technique relies on measuring changes in the damping of the oscillating tip in a magnetic force microscope (MFM). Damping contrast is strongly correlated with…
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Neural activity associated with overcoming retroactive interference in episodic memory was investigated with event-related brain potentials (ERPs). ERPs were recorded during a combined recognition/associative recall memory test in which subjects…
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Excess brain zinc has been implicated in Alzheimer's neuropathology. Here we evaluated that hypothesis by searching the brains of Alzheimer's patients for abnormal zinc deposits. Using histochemical methods, we found vivid Zn2+ staining in the…
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Senior LecturerBangalore, India -
Student (Master)Florianópolis, Brazil -
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Student (Master)Lancaster University