The -174 G/C polymorphism [rs1800795] of the IL6 gene is a candidate to explain individual variations in health and exercise related phenotypes. We compared -174 G/C genotypic and allelic frequencies in three groups of men of the same Caucasian (Spanish) descent: elite endurance athletes (cyclists, runners; n= 100); elite power athletes (jumpers, throwers, sprinters; n= 53) and non-athletic controls (n= 100). The frequency of the GG genotype (P= 0.030) and G allele (P= 0.026) was higher in the power athletes group compared with the control group. The frequency of the GG genotype (P= 0.033) and G allele (P= 0.013) was also higher in the power athletes group compared with the endurance athletes group. The odds ratio of being a power athlete if the subject had the GG genotype (dominant model) was 2.471 (95% confidence interval: 1.242-4.915) compared to the control group or the endurance athlete group. We did not find differences between the control and endurance athlete groups. In summary, our findings suggest that the G allele of the IL6-174 G/C polymorphism might favour sprint/power sports performance. © 2009 Sports Medicine Australia.
CITATION STYLE
Ruiz, J. R., Buxens, A., Artieda, M., Arteta, D., Santiago, C., Rodríguez-Romo, G., … Lucia, A. (2010). The -174 G/C polymorphism of the IL6 gene is associated with elite power performance. Journal of Science and Medicine in Sport, 13(5), 549–553. https://doi.org/10.1016/j.jsams.2009.09.005
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