Recently, the gene called DAAO was reported to be associated with schizophrenia in the French Canadian populations. Here, we report a result obtained in the study of our large collection of 547 schizophrenia cases and 536 controls in the Chinese population. Six single-nucleotide polymorphisms (SNPs) were genotyped at and around the DAAO locus, covering a 10-kb region entirely encompassing the complementary DNA sequences of DAAO. We found statistically significant differences in allele distributions on one marker: SNP rs3741775 (P = 0.0000001). In the haplotype analysis based on the information of linkage-disequilibrium block across this gene locus, we demonstrated a highly significant association between schizophrenia and a DAAO haplotype (P = 2.0173 × 10 -21), which therefore provides an independent statistical support for association of the DAAO gene with schizophrenia and indicates that the DAAO gene may play a significant role in the etiology of schizophrenia in the Han Chinese. © 2004 Elsevier Ireland Ltd. All rights reserved.
CITATION STYLE
Liu, X., He, G., Wang, X., Chen, Q., Qian, X., Lin, W., … He, L. (2004). Association of DAAO with schizophrenia in the Chinese population. Neuroscience Letters, 369(3), 228–233. https://doi.org/10.1016/j.neulet.2004.07.078
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