The association of obstructive sleep apnea with single nucleotide polymorphisms located near the CDKN2A/2B loci on chromosome 9P21

  • Fedson A
  • Mukherjee S
  • Hung J
  • et al.
ISSN: 1446-9235
N/ACitations
Citations of this article
2Readers
Mendeley users who have this article in their library.

Abstract

Background: Genetic variants located near CDKN2A/2B loci are associated with insulin resistance and cardiovascular disease (CVD) risk. It is unknown whether these polymorphisms are independently associated with obstructive sleep apnea (OSA). The aim of this study was to investigate CDKN2A/2B variant associations with OSA risk and severity, adjusting for conventional confounders. Methods: Four single nucleotide polymorphisms (SNPs) were genotyped and analyzed in an OSA case population (Western Australian Sleep Health Study) and compared with two general population control groups (Busselton Health Surveys). Sleep clinic cases were defined by AHI more than or equal to 5 from overnight polysomnography. Community controls included: (a) unselected participants and (b) those with low OSA probability as determined by sleep questionnaire. Subjects were assessed for hypertension, diabetes, CVD and metabolic syndrome. Sex-stratified generalized linear modelling characterized multivariate associations adjusted for age, body mass index (BMI), smoking and other co-morbidities. Results: There were 973 cases, 4,772 unselected controls, and 1,526 controls with low OSA probability. Case-control analysis indicated significant interactions between diabetes and the rs10811661 and rs564398 SNPs on OSA risk in women. Within OSA cases, multivariate analyses indicated significant SNP associations with OSA and CVD associated phenotypes independently of BMI and other confounders (P less than 0.05). Variant rs10757278 was significantly associated with diabetes, and a SNP:diabetes interaction was significantly associated with loge(AHI) (P less than 0.05). Conclusions: These results suggest pleiotropic loci near the CDKN2A/2B region are associated with OSA both in association with and independently of cardiovascular and metabolic factors. Replication analyses and functional genetic investigations are required to determine causality.

Cite

CITATION STYLE

APA

Fedson, A., Mukherjee, S., Hung, J., Lee, J. D., Simpson, L., Ward, K. L., … Palmer, L. J. (2011). The association of obstructive sleep apnea with single nucleotide polymorphisms located near the CDKN2A/2B loci on chromosome 9P21. Sleep and Biological Rhythms, 9(4), 270. Retrieved from http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L70572486

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free