Current standard therapy for Wegener's granulomatosis and microscopic polyangiitis combines corticosteroids and cyclophosphamide to induce remission, followed by a less toxic immunosuppressant such as azathioprine or methotrexate for maintenance therapy. However, azathioprine and methotrexate have not been compared with regard to safety and efficacy.
CITATION STYLE
Pagnoux, C., Mahr, A., Hamidou, M. A., Boffa, J.-J., Ruivard, M., Ducroix, J.-P., … Guillevin, L. (2008). Azathioprine or Methotrexate Maintenance for ANCA-Associated Vasculitis. New England Journal of Medicine, 359(26), 2790–2803. https://doi.org/10.1056/nejmoa0802311
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