Surface-associated bacteria typically form self-organizing communities called biofilms. Spatial segregation is important for various bacterial processes associated with cellular and community development. Here, we demonstrate bacterial ordering and oriented attachment on the single-cell level induced by nanometer-scale periodic surface features. These surfaces cause spontaneous and distinct patterning phases, depending on their periodicity, which is observed for several strains, both gram positive and negative. This patterning is a general phenomenon that can control natural biofilm organization on the cellular level. © 2010 American Chemical Society.
CITATION STYLE
Hochbaum, A. I., & Aizenberg, J. (2010). Bacteria pattern spontaneously on periodic nanostructure arrays. Nano Letters, 10(9), 3717–3721. https://doi.org/10.1021/nl102290k
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