The ability of B lymphocytes to capture, process and present antigens to T cells is requisite for normal humoral immune responses and contributes to the pathogenesis of both B- and T-cell-mediated autoimmune diseases. B lymphocytes preferentially capture polyvalent antigens, which are capable of eliciting a coordinated series of cellular responses that ensure that even low-affinity antigens are productively captured. Polyvalency not only accelerates transit through the endocytic pathway but also induces a reorganization of the antigen-processing compartment, activates degradative pathways and determines how antigenic peptides are presented to T cells. Similar changes are observed in maturing dendritic cells, indicating that some cellular responses to foreign antigens are conserved.
CITATION STYLE
Clark, M. R., Massenburg, D., Siemasko, K., Hou, P., & Zhang, M. (2004, June). B-cell antigen receptor signaling requirements for targeting antigen to the MHC class II presentation pathway. Current Opinion in Immunology. https://doi.org/10.1016/j.coi.2004.03.007
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