Common variants in ZNF365 are associated with both mammographic density and breast cancer risk

Abstract

High-percent mammographic density adjusted for age and body mass index is one of the strongest risk factors for breast cancer. We conducted a meta analysis of five genome-wide association studies of percent mammographic density and report an association with rs10995190 in ZNF365 (combined P = 9.6 × 10-10). Common variants in ZNF365 have also recently been associated with susceptibility to breast cancer. © 2011 Nature America, Inc. All rights reserved.