One of the largest contributors to chlorinated solvent waste in medicinal chemistry is chromatography. A set of "drug-like" compounds was employed to compare the relative eluting strengths of greener solvent systems. Disclosed herein is an experimentally-derived solvent selection guide to aid chemists in choosing greener solvents for chromatographic purification, with a particular focus on reducing dichloromethane usage. © 2012 The Royal Society of Chemistry.
CITATION STYLE
Taygerly, J. P., Miller, L. M., Yee, A., & Peterson, E. A. (2012). A convenient guide to help select replacement solvents for dichloromethane in chromatography. Green Chemistry, 14(11), 3020–3025. https://doi.org/10.1039/c2gc36064k
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