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The distinctive biology of cancer in adolescents and young adults

by Archie Bleyer, Ronald Barr, Brandon Hayes-Lattin, David Thomas, Chad Ellis, Barry Anderson, Biology, Clinical Trials Subgroups of the US National Cancer Institute Progress Review Group in Adolescent, Young Adult Oncology show all authors
Nat Rev Cancer ()

Abstract

One explanation for the relative lack of progress in treating cancer in adolescents and young adults is that the biology of malignant diseases in this age group is different than in younger and older persons, not only in the spectrum of cancers but also within individual cancer types and within the patient (host). Molecular, epidemiological and therapeutic outcome comparisons offer clues to this distinctiveness in most of the common cancers of adolescents and young adults. Translational and clinical research should not assume that the biology of cancers and patients is the same as in other age groups, and treatment strategies should be tailored to the differences.

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