Objective: An interaction between predisposing genes and environmental stressors is thought to underlie the neurodevelopmental disorder schizophrenia. In a targeted gene screening, we previously found that the minor allele of the single nucleotide polymorphism (SNP) rs6336 in the neurotrophic tyrosine kinase receptor 1 (NTRK1/TRKA) gene is associated with schizophrenia as a risk factor. Methods: We genotyped the TRKA SNP in a total of eight independent Caucasian schizophrenia case-control groups. Result: Remarkably, although in five of the groups a higher frequency of the risk allele was indeed found in the patients compared with the controls, in the three other groups the SNP acted as a protective factor. Conclusion: An intriguing possibility is that this dual character of the TRKA SNP is caused by its interaction with endophenotypic and/or epistatic factors. © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.
CITATION STYLE
Van Schijndel, J. E., Van Zweeden, M., Van Loo, K. M. J., Djurovic, S., Andreassen, O. A., Hansen, T., … Martens, G. J. M. (2011). Dual association of a TRKA polymorphism with schizophrenia. Psychiatric Genetics, 21(3), 125–131. https://doi.org/10.1097/YPG.0b013e3283437194
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