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Efficacy of erlotinib for brain and leptomeningeal metastases in patients with lung adenocarcinoma who showed initial good response to gefitinib.

by Tatsuya Katayama, Junichi Shimizu, Kenichi Suda, Ryoichi Onozato, Takayuki Fukui, Simon Ito, Shunzo Hatooka, Taijiro Sueda, Toyoaki Hida, Yasushi Yatabe, Tetsuya Mitsudomi show all authors
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer ()

Abstract

The efficacy of high-dose (1250 mg/d) gefitinib for the treatment of leptomeningeal metastasis in a patient with lung cancer harboring a mutation in the epidermal growth factor receptor (EGFR) gene was previously reported. We speculate that erlotinib, instead of high dose of gefitinib, may be also effective for the treatment of central nervous system (CNS) lesions, as trough serum concentration of erlotinib is nine times higher than that of gefitinib.

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