Expanding cyclitol structural diversity by biocatalysis and metalocatalysis. A click chemistry approach.

Expanding cyclitol structural diversity by biocatalysis and metalocatalysis. A click chemistry approach.

by Victoria De La Sovera, Ana Bellomo, Jesus M Pena, David Gonzalez, Hélio A Stefani

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Molecular Diversity (2011)

Volume: 15, Issue: 1, Pages: 163-172

PubMed: 20198422

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Abstract

The palladium catalyzed cross-coupling reaction of phenyltrifluoroborate with a chemoenzymatically derived bromoazidoconduritol, combined with 1,3-dipolar cycloaddition, with a variety of alkynes is described. Fourteen new compounds were synthesized in moderate to good yields. The click chemistry reaction can be effected by using sodium ascorbate and CuSO(4) 5H(2)O as catalyst in toluene-H(2)O at room temperature.

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Expanding cyclitol structural div...

123 Molecular Diversity ISSN 1381-1991 Volume 15 Number 1 Mol Divers (2011) 15:163-172 DOI 10.1007/ s11030-010-9237-6 Expanding cyclitol structural diversity by biocatalysis and metalocatalysis. A click chemistry approach

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