Sparked by the discovery of LSD1, the first bona fide histone lysine demethylase, a burst of research has opened a new era in understanding how chromatin is regulated, including the identification of the JmjC domain-containing histone demethylases. Now, several independent studies provide evidence that yeast Yjr119Cp, human JARID1 and Drosophila Lid, all members of the JmjC family, demethylate histone H3 trimethyl-Lys4, a mark of transcriptionally active chromatin. © 2007 Nature Publishing Group.
CITATION STYLE
Metzger, E., & Schüle, R. (2007, April). The expanding world of histone lysine demethylases. Nature Structural and Molecular Biology. https://doi.org/10.1038/nsmb0407-252
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