Abstract
Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10 10 to 10 15). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 × 10 5 and P = 3.6 × 10 4, respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease. © 2010 Nature America, Inc. All rights reserved.
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CITATION STYLE
Chambers, J. C., Zhang, W., Lord, G. M., Van Der Harst, P., Lawlor, D. A., Sehmi, J. S., … Kooner, J. S. (2010). Genetic loci influencing kidney function and chronic kidney disease. Nature Genetics, 42(5), 373–375. https://doi.org/10.1038/ng.566
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