Genetic variations in radiation and chemotherapy drug action pathways predict clinical outcomes in locoregionally advanced nasopharyngeal carcinoma

Abstract

OBJECTIVE: To investigate the correlation between the gene polymorphisms of radiotherapy, chemotherapy action pathways and the prognosis of the patients with locoregionally advanced nasopharyngeal carcinoma (NPC). METHODS: A total of 203 locoregionally advanced NPC patients were enrolled in the study. 18 single nucleotide polymorphisms (SNPs) belong to 13 genes in the radiotherapy and chemotherapy action pathways were examined. Kaplan-Meier method and Cox regression model were employed for analysis. RESULTS: Kaplan-Meier analysis showed that the patients carried rs25487 AA, rs1136410 CC + TT genotypes had lower OS (overall survival rates); the patients carried rs2032582 AT genotype had lower LRFS (locoregional relapse free survival rates); the patients carried rs25487 AA, rs2010963 CC, rs833061 CT + TT genotypes had lower DMFS (distant metastasis free survival rates); the patients carried rs3212986 GG, rs25487 AA, rs2032582 AT, rs2279744 GG + GT genotypes had lower PFS (progress free survival rates). Cox analysis showed that the aforementioned SNPs were the independent influence factors to the correspondingly survival rates except rs833061 (P<0.05). CONCLUSION: A few SNPs in radiotherapy or chemotherapy action pathways are prognostic factors for patients with locoregionally advanced NPC, which provided new molecular factors to evaluate the prognosis and perform individualized treatments.