Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility

Abstract

We report a prostate cancer genome-wide association follow-on study. We discovered four variants associated with susceptibility to prostate cancer in several European populations: rs10934853[A] (OR = 1.12, P = 2.9 × 1010) on 3q21.3; two moderately correlated (r2 = 0.07) variants, rs16902094[G] (OR = 1.21, P = 6.2 × 1015) and rs445114[T] (OR = 1.14, P = 4.7 × 1010), on 8q24.21; and rs8102476[C] (OR = 1.12, P = 1.6 × 1011) on 19q13.2. We also refined a previous association signal on 11q13 with the SNP rs11228565[A] (OR = 1.23, P = 6.7 × 1012). In a multivariate analysis using 22 prostate cancer risk variants typed in the Icelandic population, we estimated that carriers in the top 1.3% of the risk distribution are at a 2.5 times greater risk of developing the disease than members of the general population. © 2009 Nature America, Inc. All rights reserved.