In this study we report convincing statistical support for a sixth type 1 diabetes (T1D) locus in the innate immunity viral RNA receptor gene region IFIH1 (also known as mda-5 or Helicard) on chromosome 2q24.3. We found the association in an interim analysis of a genome-wide nonsynonymous SNP (nsSNP) scan, and we validated it in a case-control collection and replicated it in an independent family collection. In 4,253 cases, 5,842 controls and 2,134 parent-child trio genotypes, the risk ratio for the minor allele of the nsSNP rs1990760 A → G (A946T) was 0.86 (95% confidence interval ≤ 0.82-0.90) at P ≤ 1.42 × 10-10. © 2006 Nature Publishing Group.
CITATION STYLE
Smyth, D. J., Cooper, J. D., Bailey, R., Field, S., Burren, O., Smink, L. J., … Todd, J. A. (2006). A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nature Genetics, 38(6), 617–619. https://doi.org/10.1038/ng1800
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