The evaluation of susceptibility loci is an important addition to the current predictive and screening models in type 1 diabetes of Chinese Han population. Therefore, the aim of this study is to provide evidence for the association between type 1 diabetes and two polymorphisms (rs3747517, rs1990760) from interferon induced with helicase C domain 1 (IFIH1). Here, 464 Type 1 diabetespatients and 465 control subjects were genotyped for these 2 polymorphisms. The results indicated that the allelic frequencies of rs3747517 revealed a strong association with type 1 diabetes risk (P < 0.001); yet, no significant association was observed on rs1990760(P = 0.76). Furthermore, IFIH1 rs3747517 polymorphism had no influence on the positive rates of pancreatic auto-antibodies, and both of the polymorphisms had no interaction with HLA class I-linked risk or phenotypes. In conclusion, IFIH1 rs3747517, but not rs1990760 polymorphism, plays an important role in type 1 diabetes risk in Chinese Han population. © Informa UK, Ltd.
CITATION STYLE
Yang, H., Wang, Z., Xu, K., Gu, R., Chen, H., Yu, D., … Yang, T. (2012). IFIH1 gene polymorphisms in type 1 diabetes: Genetic association analysis and genotype-phenotype correlation in Chinese Han population. Autoimmunity, 45(3), 226–232. https://doi.org/10.3109/08916934.2011.633134
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