OBJECTIVE- To explore the association between epistasis among related genes of the renin-angiotensin system (RAS) and type 2 diabetes. RESEARCH DESIGN AND METHODS- Gene polymorphisms were genotyped in 394 type 2 diabetic patients and 418 healthy control subjects in this case-control study. We used the multifactor dimensionality reduction method to identify gene-gene interactions. RESULTS- No single locus was associated with type 2 diabetes, except for the insert/deletion (I/D) polymorphism of the ACE gene in female subjects. In multi-locus analyses, in male subjects the model of rs2106809 (ACE2), rs220721 (Mas), rs699 (AGT), and I/D (ACE) was significant (P = 0.043). This combination was associated with a 4.00 times (95% CI 2.51-6.38; P < 0.0001) greater prevalence of type 2 diabetes. In female subjects, the model of rs2106809 (ACE2), I/D (ACE), and rs1403543 (AGTR2) was significant (P = 0.012). This three-locus combination was associated with a 2.76 times (1.91-3.97; P < 0.0001) greater prevalence of type 2 diabetes. CONCLUSIONS- Interactions among RAS-related genes were associated with type 2 diabetes in a Chinese population. © 2010 by the American Diabetes Association.
CITATION STYLE
Yang, J. K., Zhou, J. B., Xin, Z., Zhao, L., Yu, M., Feng, J. P., … Ma, Y. H. (2010). Interactions among related genes of renin-angiotensin system associated with type 2 diabetes. Diabetes Care, 33(10), 2271–2273. https://doi.org/10.2337/dc10-0349
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