Invivo evaluation of antiarthritic activity of seed coat of Tamarindus Indica Linn.

Abstract

Introduction: The Alcoholic and Aqueous extract of seed coat of Tamarindus Indica Linn. of family Ceasalpiniaceae was studied for anti-arthritic activity against Freund's Complete Adjuvant induced arthritis in Wister Albino rats of either sex., the active phenolic component in Tamarindus Indica Linn extract. Methods: The antiarthritic activities of Tamarindus Indica Linn extract were investigated on rat models of arthritis by Freund's Complete Adjuvant in rats induced acute paw pain and arthritis, evaluated by measuring the squeaking score, paw volume, and weight distribution ratio. The alcoholic and aqueous extract of seed coat of Tamarindus Indica Linn was administrated orally to rats for 19 days. Results: Tamarindus Indica Linn inhibited the expression of IL and reduced the production of PGE2. Both extracts (aqeous and alcoholic) were found to significantly inhibit paw edema induced arthritis by Freund's Complete Adjuvant in rats. The result indicates that alcoholic extract of seed coat of Tamarindus Indica Linn. had significant (P<0.01) anti-arthritic activity when compared with standard and untreated control. Conclusions: These results suggest that Tamarindus Indica Linn has anti-inflammatory, antinociceptive, and antiarthritic effects in an arthritis animal model. Thus, Tamarindus Indica Linn should be further studied with regard to use either as a pharmaceutical or as a dietary supplement for the treatment of arthritis.