Lack of association of IL-10 gene polymorphisms with prostate cancer: Evidence from 11,581 subjects

Abstract

Published data on the association between interleukin-10 (IL-10) gene polymorphisms and prostate cancer (PCa) are inconclusive. To derive a more precise estimation of the association, we conducted a meta-analysis. Data were collected from the following electronic databases: PubMed, Elsevier Science Direct, Excerpta Medica Database and Chinese Biomedical Literature Database, with the last report up to September 2010. The odds ratio (OR) and its 95% confidence interval (95%CI) were used to assess the strength of association. A total of 13 separate studies including 5503 cases and 6078 controls based on the search criteria were involved in this meta-analysis. Meta-analysis was performed for three IL-10 gene polymorphisms (rs1800896, rs1800871, and rs1800872). We found no association between IL-10 gene rs1800896 polymorphism and PCa in overall population (G versus A: OR = 1.00, 95%CI = 0.91-1.10, P = 0.99; AG + GG versus AA: OR = 1.18, 95%CI = 0.97-1.43, P = 0.10; GG versus AA + AG: OR = 1.04, 95%CI = 0.86-1.26, P = 0.67). In subgroup analysis, similar results were found in Caucasian (G versus A: OR = 0.99, 95%CI = 0.84-1.18, P = 0.92; AG + GG versus AA: OR = 1.32, 95%CI = 0.90-1.94, P = 0.16; GG versus AA + AG: OR = 1.07, 95%CI = 0.89-1.28, P = 0.48), and Asian (G versus A: OR = 0.97, 95%CI = 0.78-1.20, P = 0.78; AG + GG versus AA: OR = 1.07, 95%CI = 0.79-1.45, P = 0.65; GG versus AA + AG: OR = 1.24, 95%CI = 0.38-4.07, P = 0.73) populations. We did not detect an association between IL-10 gene rs1800871 polymorphism and PCa in overall population (T versus C: OR = 0.96, 95%CI = 0.85-1.08, P = 0.51; CT + TT versus CC: OR = 0.94, 95%CI = 0.80-1.11, P = 0.48; TT versus CC + CT: OR = 0.94, 95%CI = 0.81-1.10, P = 0.44). Similar results were found in Asian population (T versus C: OR = 0.85, 95%CI = 0.71-1.09, P = 0.09; CT + TT versus CC: OR = 0.72, 95%CI = 0.52-1.17, P = 0.05; TT versus CC + CT: OR = 0.89, 95%CI = 0.68-1.17, P = 0.39). We found no association between IL-10 gene rs1800872 polymorphism and PCa in overall population (A versus C: OR=1.03, 95%CI = 0.96-1.11, P = 0.41; CA + AA versus CC: OR = 1.04, 95%CI = 0.92-1.17, P = 0.56; AA versus CC + CA: OR = 1.02, 95%CI = 0.85-1.22, P = 0.87). Similar results were found in Caucasian population (A versus C: OR = 1.06, 95%CI = 0.98-1.16, P = 0.16; CA + AA versus CC: OR = 1.07, 95%CI = 0.85-1.35, P = 0.57; AA versus CC + CA: OR = 1.23, 95%CI = 0.92-1.64, P = 0.17). This meta-analysis suggests that there is no association between IL-10 gene rs1800896, rs1800871 and rs1800872 polymorphisms and PCa. © 2010 Elsevier Ltd. All rights reserved.