We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 × 10 9), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 × 10 9), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation.
CITATION STYLE
Perry, J. R. B., Stolk, L., Franceschini, N., Lunetta, K. L., Zhai, G., McArdle, P. F., … Murabito, J. M. (2009). Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. Nature Genetics, 41(6), 648–650. https://doi.org/10.1038/ng.386
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