Microwave-assisted chemical ligation of S-acyl peptides containing non-terminal cysteine residues

18Citations
Citations of this article
30Readers
Mendeley users who have this article in their library.
Get full text

Abstract

An efficient approach for the synthesis of a series of S-acyl peptides containing internal cysteine residues has been developed and the chemical long-range ligation of these S-acyl peptides via 5-, 8-, 11- and 14-membered cyclic transition states has been investigated. Our results include the first examples of successful isopeptide ligations starting from S-acyl peptides containing non-terminal cysteine residues and indicate that the cyclic transition states studied in this present paper are decreasingly favored in the order of their sizes 5≫14>11≫8. © 2011 The Royal Society of Chemistry.

Cite

CITATION STYLE

APA

Hansen, F. K., Ha, K., Todadze, E., Lillicotch, A., Frey, A., & Katritzky, A. R. (2011). Microwave-assisted chemical ligation of S-acyl peptides containing non-terminal cysteine residues. Organic and Biomolecular Chemistry, 9(20), 7162–7167. https://doi.org/10.1039/c1ob05740e

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free