Osteoclasts are derived following the fusion of precursors of hematopoietic and myelomonocytic origin after appropriate stimulus, such as that afforded by RANKL and M-CSF. Thus the osteoclast can be considered as a specialized type of macrophage, and several of the factors that affect osteoclast formation also have affects upon macrophage differentiation. Inhibitors of osteoclast formation may perturb RANKL or M-CSF signalling or affect other signalling pathways. Several of these inhibitors are discussed with the view of their capacity to influence osteoclast differentiation, but not necessarily their activity. © 2004 Elsevier Inc. All rights reserved.
CITATION STYLE
Quinn, J. M. W., & Gillespie, M. T. (2005, March 18). Modulation of osteoclast formation. Biochemical and Biophysical Research Communications. Academic Press Inc. https://doi.org/10.1016/j.bbrc.2004.11.076
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