Genome-wide association studies (GWAS) identify genetic variants that distinguish a control population from a population with a specific trait. Two challenges in GWAS are: (1) identification of the causal variant within a longer haplotype that is associated with the trait; (2) identification of causal variants for polygenic traits that are caused by variants in multiple genes within a pathway. We review recent methods that use information in protein-protein and protein-DNA interaction networks to address these two challenges. © 2013 Elsevier Ltd.
CITATION STYLE
Leiserson, M. D. M., Eldridge, J. V., Ramachandran, S., & Raphael, B. J. (2013, December). Network analysis of GWAS data. Current Opinion in Genetics and Development. https://doi.org/10.1016/j.gde.2013.09.003
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