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Neurologic uses of botulinum neurotoxin type A

by John P. Ney, Kevin R. Joseph
Neuropsychiatric Disease and Treatment ()

Abstract

This article reviews the current and most neurologic uses of botulinum neurotoxin type A (BoNT-A), beginning with relevant historical data, neurochemical mechanism at the neuromuscular junction. Current commercial preparations of BoNT-A are reviewed, as are immunologic issues relating to secondary failure of BoNT-A therapy. Clinical uses are summarized with an emphasis on controlled clinical trials (as appropriate), including facial movement disorders, focal neck and limb dystonias, spasticity, hypersecretory syndromes, and pain.

Cite this document (BETA)

Available from www.ncbi.nlm.nih.gov
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15 Readers on Mendeley
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33% Student (Master)
 
13% Ph.D. Student
 
13% Student (Bachelor)
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7% Brazil

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