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Normal Tissue Tolerance Dose Metrics for Radiation Therapy of Major Organs

by Michael T. Milano, Louis S. Constine, Paul Okunieff
Seminars in Radiation Oncology ()

Abstract

Late organ toxicity from therapeutic radiation is a function of many confounding variables. The total dose delivered to the organ and the volumes of organ exposed to a given dose of radiation are 2 important variables that can be used to predict the risk of late toxicity. Three-dimensional radiation planning enables accurate calculation of the volume of tissue exposed to a given dose of radiation, graphically depicted as a dose-volume histogram. Dose metrics obtained from this 3-dimensional dataset can be used as a quantitative measure to predict late toxicity. This review summarizes the published clinical data on the risk of late toxicity as a function of quantitative dose metrics and attempts to offer suggested dose constraints for radiation treatment planning. © 2007 Elsevier Inc. All rights reserved.

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