Plasma cell leukemia

Abstract

Plasma cell leukemia is a rare subtype of plasma cell dyscrasias with an aggressive clinical course and poor prognosis. Despite significant advancements in therapeutics for multiple myeloma, we continue to have poor outcomes in patients with plasma cell leukemia. In this chapter, the clinical presentation and diagnosis of plasma cell leukemia are reviewed, as well as a summary of current data available on treatment options and potential future treatment directions for this difficult disease entity.