Sign up & Download
Sign in

Platelet count, mean platelet volume and thrombocytopoietic indices in healthy women and men

by Anna M. Butkiewicz, Halina Kemona, Violetta Dymicka-Piekarska, Joanna Matowicka-Karna, Piotr Radziwon, Alina Lipska
Thrombosis Research ()

Abstract

Gender-dependent differences in platelet count have been demonstrated in few studies. In women platelet count is higher than in men, which seems to reflect different hormonal profiles or a compensatory mechanism associated with menstrual blood loss. The aim of the study was to assess platelet count, mean platelet volume and thrombocytopoietic indices in women and men. The study was conducted on healthy blood donors divided into groups: F - 60 women and M - 65 men. Platelet count and mean platelet volume were determined on a haematological analyser Advia 120, Bayer. The following thrombocytopoietic indices were measured: thrombopoietin concentration (ELISA), percentage of reticulated platelets (flow cytometry, COULTER EPICS XL) and absolute reticulated platelet count. Results: Higher platelet count was noted in the group of women 252.35 ?? 41.25 ?? 109/l as compared to men 221.87 ?? 37.63 ?? 109/l (p = 0.0002). At the same time women had lower thrombopoietin concentration 156.50 ?? 57.18 pg/ml compared to men 180.46 ?? 60.98 pg/ml, (p = 0.03). No statistically significant differences were found in the mean platelet volume, percentage of reticulated platelets or absolute reticulated platelet count between group F and M. Conclusions: Platelet count is gender-dependent, being higher in women than in men. Thrombopoietin concentration is gender-dependent and is lower in women than in men. In physiological conditions, there is no correlation between platelet count and thrombopoietin concentration in women (r = - 0.155) and men (r = - 0.2586). ?? 2006.

Cite this document (BETA)

Available from Thrombosis Research
Page 1
hidden
Page 2
hidden

Readership Statistics

8 Readers on Mendeley
by Discipline
 
 
by Academic Status
 
38% Student (Master)
 
13% Other Professional
 
13% Ph.D. Student
by Country
 
13% Spain

Sign up today - FREE

Mendeley saves you time finding and organizing research. Learn more

  • All your research in one place
  • Add and import papers easily
  • Access it anywhere, anytime

Start using Mendeley in seconds!

Already have an account? Sign in