Gene x environment (G x E) interactions mediating depressive symptoms have been separately identified in the stress-sensitive serotonergic (5-HTTLPR) and corticotropin-releasing hormone (CRHR1) systems. Our objective was to examine whether the effects of child abuse are moderated by gene x gene gene (G x G) interactions between CRHR1 and 5-HTTLPR polymorphisms. We used an association study examining G x G x E interactions of CRHR1 and 5-HTTLPR polymorphisms and measures of child abuse on adult depressive symptomatology. The participant population (N = 1,392) was African-American, of low socioeconomic status (60% with
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Ressler, K. J., Bradley, B., Mercer, K. B., Deveau, T. C., Smith, A. K., Gillespie, C. F., … Binder, E. B. (2010). Polymorphisms in CRHR1 and the serotonin transporter loci: Gene x gene x environment interactions on depressive symptoms. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 153(3), 812–824. https://doi.org/10.1002/ajmg.b.31052
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