Abstract
The involvement of inflammasome genes in the susceptibility to HIV-1 infection was investigated. Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects and 158 healthy controls. The 2 polymorphisms rs10754558 in NLRP3 and rs1143634 in IL1B were significantly associated to the HIV-1 infection. These findings supported the previously hypothesized involvement of NALP3-inflammasome in HIV-1 pathogenesis, underlining once more the key role of inflammation and innate immunity in the susceptibility to HIV-1 infection. Copyright © 2012 Lippincott Williams & Wilkins.
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Pontillo, A., Oshiro, T. M., Girardelli, M., Kamada, A. J., Crovella, S., & Duarte, A. J. S. (2012). Polymorphisms in inflammasome’ genes and susceptibility to HIV-1 infection. Journal of Acquired Immune Deficiency Syndromes, 59(2), 121–125. https://doi.org/10.1097/QAI.0b013e3182392ebe
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