Individuals homozygous for haplotypes -2578-A/-1154-A/-634-G or -2578-A/-1154-G/-634-G in the promoter/5′UTR of the VEGF gene have a 1.8-fold increased risk of ALS in several European populations. We did not observe any significant association with single markers, or haplotype pairs, in a German sample of 580 sporadic ALS patients and 628 controls. However, the promoter SNP-1154 (rs1570360) was associated with affection status in women (p = 0.036), suggesting that the VEGF effect may be dependent on the sex ratio of the sample. Copyright © 2006 by AAN Enterprises, Inc.
CITATION STYLE
Fernández-Santiago, R., Sharma, M., Mueller, J. C., Gohlke, H., Illig, T., Anneser, J., … Gasser, T. (2006). Possible gender-dependent association of vascular endothelial growth factor (VEGF) gene and ALS. Neurology, 66(12), 1929–1931. https://doi.org/10.1212/01.wnl.0000219756.71928.25
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