We present proof-of-concept studies that display the potential for using a glucose-sensitive hydrogel as a continuous glucose sensor. A study to characterize the swelling ratio of the hydrogel at normal physiological and pathological hyperglycemic glucose levels was performed. The hydrogel exposed to the hyperglycemic glucose solution had a higher equilibrium swelling ratio than the hydrogel exposed to the normal glucose concentration solution. The diffusivity of a small molecule, fluorescein isothiocyanate (FITC), through a hydrogel exposed to a hyperglycemic solution was determined using fluorescence recovery after photobleaching (FRAP). The diffusivity was found to be 4.2 × 10-14 m2/s, a value approximately four orders of magnitude smaller than the diffusivity of FITC in glucose solution. The permeability of the hydrogel after equilibration in a hyperglycemic solution was found to be 5.1 × 10-17 m2, in the range of 2-4% agarose gels. © 2010 IEEE.
CITATION STYLE
Beier, B. L., Brandner, E. M., Musick, K. M., Matsumoto, A., Panitch, A., Nauman, E. A., & Irazoqui, P. P. (2010). Preliminary characterization of a glucose-sensitive hydrogel. In 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC’10 (pp. 5014–5017). https://doi.org/10.1109/IEMBS.2010.5627210
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