A survey of a series of organosilyl derivatives of serine and tyrosine has shown that they have a satisfactory stability profile for use in peptide synthesis. Only when alkaline conditions were used did side-reactions appear. A range of stability profiles have been determined from a study of organosilyl derivatised dipeptides under different conditions, giving t1/2-values for hydrolysis ranging from 41 to 465 min in acid conditions, yet giving long-term stability at pH-values near to neutrality.
CITATION STYLE
Davies, J. S., Higginbotham, C. L., Tremeer, E. J., Brown, C., & Treadgold, R. C. (1992). Protection of hydroxy groups by silylation: Use in peptide synthesis and as lipophilicity modifiers for peptides. Journal of the Chemical Society, Perkin Transactions 1, (22), 3043–3048. https://doi.org/10.1039/p19920003043
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