Rodent models for autism: A critical review

Abstract

We review 15 rodent models proposed for exploring autistic behaviours. There are two main types of behavioural tests that are relevant to autism, these include tests of social behaviour and communication and tests of stereotypy and cognitive rigidity. Only few of these models have been tested for both of these types of behaviours. Furthermore, very few attempts have been made to test medications known to improve certain symptoms of patients. Finally, potential transgenic mouse models in addition to toxic and lesion models are discussed. © 2005 Elsevier Ltd. All rights reserved.