The rs1801278 G>A polymorphism of IRS-1 is associated with metabolic syndrome in healthy nondiabetic men. Modulation by cigarette smoking status

Abstract

Aims: To explore associations between IRS-1 rs1801278 G. > A polymorphism and metabolic syndrome (MS). Methods: rs1801278 G. > A was genotyped in 610 healthy Argentinian men. Results: GA carriers had lower risk of MS (OR = 0.52, P= 0.045), particularly among smokers (OR = 0.10, P= 0.006). Conclusions: rs1801278 GA carriers had lower risk of MS, especially among smokers. © 2011 Elsevier Ireland Ltd.