HPV vaccines available in the market are not effective against different strains of papillomavirus, therefore, there is a need to develop a new prophylactic DNA vaccine which can work against different strains of HPVs and may lead to protection of cervical cancer against new pandemic viruses. We designed a potential prophylactic DNA vaccine by using all the consensus epitopic sequences of HPVs L2 capsid protein and performed in silico cloning of multiepitopic antigenic DNA sequence in pVAX-1 vector. Immunogenicity of vaccine has been enhanced by techniques like codon optimization, engineering CpG motifs, introducing promoters and co-injection with plasmids expressing immune-stimulatory molecules. © 2009 Elsevier Ltd. All rights reserved.
CITATION STYLE
Gupta, S. K., Singh, A., Srivastava, M., Gupta, S. K., & Akhoon, B. A. (2009). In silico DNA vaccine designing against human papillomavirus (HPV) causing cervical cancer. Vaccine, 28(1), 120–131. https://doi.org/10.1016/j.vaccine.2009.09.095
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