Biologists were puzzled by the discovery of left-handed Z-DNA because it seemed unnecessary. Z-DNA was stabilized by the negative supercoiling generated by transcription, which indicated a transient localized conformational change. Few laboratories worked on the biology of Z-DNA. However, the discovery that certain classes of proteins bound to Z-DNA with high affinity and great specificity indicated a biological role. The most recent data show that some of these proteins participate in the pathology of poxviruses.
CITATION STYLE
Rich, A., & Zhang, S. (2003, July 1). Z-DNA: The long road to biological function. Nature Reviews Genetics. https://doi.org/10.1038/nrg1115
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