Kouloulia et al. demonstrate that, during early postnatal brain development, deamidation of the translation initiation factor 4E-BP2 renders it susceptible to ubiquitination and proteasomal degradation via enhanced binding to the Raptor-CUL4B complex. mTORC1 or glutamate receptor inhibition stabilizes deamidated 4E-BP2. Moreover, deamidated 4E-BP2 regulates the translation of specific mRNAs and NF-κB activity.
CITATION STYLE
Kouloulia, S., Hallin, E. I., Simbriger, K., Amorim, I. S., Lach, G., Amvrosiadis, T., … Gkogkas, C. G. (2019). Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity. Cell Reports, 29(11), 3620-3635.e7. https://doi.org/10.1016/j.celrep.2019.11.023
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