Recently several methods have been developed for the determination of drugs and their metabolites in the lower ng/l range using solid phase extraction (SPE), derivatization, detection and confirmation by gas chromatography/mass spectrometry (GC/MS)…
Chromatography
In this subdiscipline:
25,088 papers
Popular papers
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The widespread occurrence of antibiotics as contaminants in the aquatic environment has increased attention in the last years. The concern over the release of antibiotics into the environment is related primarily to the potential for the development…
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The present paper reports on the possibility to use the kinetic plot method (KPM) to select and design the best possible system to achieve a given number (100,000) of theoretical plates for a pharmaceutical test mixture, using the information…
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This study had three objectives: 1) determine occurrence of antibiotics in effluent from hospitals, residential facilities, and dairies, and in municipal wastewater 2) determine antibiotic removal at a large wastewater treatment plant (WWTP) in…
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Analytical method was developed which allowed for the detection of four beta blockers (acebutolol, atenolol, metoprolol and sotalol), an antiepileptic drug (carbamazepine) and three fluoroquinolone antibiotics (ciprofloxacin, ofloxacin and…
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A robust new adsorptive separation technique specifically designed for direct product capture from crude bioprocess feedstreams is introduced and compared with the current bench mark technique, expanded bed adsorption. The method employs product…
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A gas chromatography-mass spectrometric (GC-MS) method has been established for the simultaneous determination of 103 pesticide residues in cabbages and apples using programmable temperature vaporizer-based large volume injection (PTV-LVI) and…
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Pesticides in foodstuff are becoming a major issue due to their intensive use in agriculture. Thus an appropriate control of their residues in food samples has to be operated. In this study we analysed 105 pesticides with GC/SQ-MS and 46 pesticides…
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Consumption of non-steroidal anti-inflammatory drugs (NSAIDs) is increasing and with it the danger of environmental pollution by pharmaceutical residues. Publications regarding NSAIDs in the environment not only show that they are toxic to many…
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We review recent liquid chromatography-tandem mass spectrometry methods using different mass spectrometers (ion-trap, triple-quadrupole and time-of-flight) for the determination of antimicrobials in the environment. Limits of detection as low as 2…
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This paper presents an overview of large-scale downstream processing of monoclonal antibodies and Fc fusion proteins (mAbs). This therapeutic modality has become increasingly important with the recent approval of several drugs from this product…
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In this paper, a wide range of antibodies from various subclasses and subfamilies are employed to evaluate the creation of generic separation processes using Protein A chromatography. The reasons for elution pH differences amongst several IgG1s,…
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Since the wide adoption of liquid chromatography/tandem mass spectrometry (LC/MS/MS), the ion suppression/enhancement phenomenon is the latest barrier to high-throughput analysis. This consequence of a nonoptimized analytical method can lead to…
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The highly complex matrix of activated sludge in sewage treatment plants (STPs) makes it difficult to detect endocrine-disrupting chemicals (EDCs) which are usually present at low concentration levels. To date, no literature has reported the…
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Proteomics is the large-scale study of proteins, particularly their expression, structures and functions. This still-emerging combination of technologies aims to describe and characterize all expressed proteins in a biological system. Because of…
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The limit of detection and limit of quantification are current critical issues in environmental testing. In most laboratories, limits are currently calculated on the basis of the standard deviation of replicate analyses at a single concentration.…
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Student (Postgraduate)UFPB - Universidade Federal da Paraíba -
Ph.D. StudentWad Madanī, Sudan -
Student (Master)Ouro Preto, Brazil -
Ph.D. StudentColumbus, Ohio, United States -
Researcher (at an Academic Institution)State Scientific Organization North Caucasian Regional Research Institute of Horticulture and Viticulture of the Russian Academy of Agricultural Sciences