Research areas such as proteomics and metabolomics are driving the demand for mass spectrometers that have high performance but modest power requirements, size, and cost. This paper describes such an instrument, the Orbitrap, based on a new type of…
Mass Spectrometry
In this subdiscipline:
78,934 papers
Popular papers
-
-
Insights into conducting research and the writing of scientific papers are given by Prof. Whitesides in this short essay. The manuscript and its guidelines has been circulated within the Whitesides' research group since 1989.
-
This tutorial presents the most common ion activation techniques employed in tandem mass spectrometry. In-source fragmentation and metastable ion decompositions, as well as the general theory of unimolecular dissociations of ions, are initially…
-
Metabolomic fingerprinting of bodily fluids can reveal the underlying causes of metabolic disorders associated with many diseases, and has thus been recognized as a potential tool for disease diagnosis and prognosis following therapy. Here we report…
-
Mass spectrometry (MS) in combination with liquid chromatography (LC), i.e. LC-MS, is the key analytical technique on which the emerging "omics" technologies of proteomics, metabolomics and lipidomics are based. It provides both structural and…
-
There is an advantage for users of electrospray and nanospray mass spectrometry to have an understanding of the processes involved in the conversion of the ions present in the solution to ions in the gas phase. The following processes are…
-
It was inevitable that as soon as mass spectrometrists were able to tell biologists which proteins were in their samples, the next question would be how much of these proteins were present. This has turned out to be a much more challenging question.…
-
Mass spectrometry (MS) techniques, because of their sensitivity and selectivity, have become methods of choice to characterize the human metabolome and MS-based metabolomics is increasingly used to characterize the complex metabolic effects of…
-
The use of linear quadrupoles in mass spectrometry as mass filters and ion guides is reviewed. Following a tutorial review of the principles of mass filter operation, methods of mass analysis are reviewed. Discussed are extensions of quadrupole mass…
-
Linear ion traps are finding new applications in many areas of mass spectrometry. In a linear ion trap, ions are confined radially by a two-dimensional (2D) radio frequency (RF) field, and axially by stopping potentials applied to end electrodes.…
-
-
MALDI imaging mass spectrometry (MALDI-IMS) has become a powerful tool for the detection and localization of drugs, proteins, and lipids on-tissue. Nevertheless, this approach can only perform identification of low mass molecules as lipids,…
-
Proteomics is the systematic analysis of the proteins expressed by a cell or tissue, and mass spectrometry is its essential analytical tool. In the past two years, incremental advances in standard proteome technology have increased the speed of…
-
Lignin, a resistant cell-wall constituent of all vascular plants that consists of ether and carbon-linked methoxyphenols, is still far from being structurally described in detail. The main problem in its structural elucidation is the difficulty of…
-
Electrospray ionization (ESI) mass spectrometry (MS) in both the positive and negative ion mode has been used to study protein unfolding transitions of lysozyme, cytochrome c (cyt c), and ubiquitin in solution. As expected, ESI of unfolded lysozyme…
-
Electrospray ionization has recently emerged as a powerful technique for producing intact ions in vacuo from large and complex species in solution. To an extent greater than has previously been possible with the more familiar "soft" ionization…
-
Collisional cooling of ions in the rf-only multipole guides has become a method of choice for coupling electrospray sources to various mass analyzers. Normally parameters of such ion guides (length, pressure) provide enough thermalization and…
-
Recent technological developments in the field of mass spectrometry have resulted in enhanced performance in traditional biotechnological applications and are opening up new approaches to a wide range of problems in protein analysis. Developments in…
-
BACKGROUND: Metabolomic studies are targeted at identifying and quantifying all metabolites in a given biological context. Among the tools used for metabolomic research, mass spectrometry is one of the most powerful tools. However, metabolomics by…
-
Ion mobility coupled with mass spectrometry has evolved into a powerful analytical technique for investigating the gas-phase structures of biomolecules. Here we present the mobility separation of some peptide and protein ions using a new hybrid…
Popular tags
Sign up today - FREE
Mendeley saves you time finding and organizing research. Learn more
- All your research in one place
- Add and import papers easily
- Access it anywhere, anytime
Start using Mendeley in seconds!
Active members
-
Post DocLeiden University -
Ph.D. StudentNanjing, China -
Assistant ProfessorUniversità degli Studi di Catanzaro Magna Graecia -
Associate ProfessorEdinburgh, United Kingdom -
Ph.D. StudentLos Angeles, California, United States