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Mass Spectrometry

In this subdiscipline: 6,788 papers
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Popular papers

  1. Research areas such as proteomics and metabolomics are driving the demand for mass spectrometers that have high performance but modest power requirements, size, and cost. This paper describes such an instrument, the Orbitrap, based on a new type of…
  2. Quantitative proteomics has traditionally been performed by two-dimensional gel electrophoresis, but recently, mass spectrometric methods based on stable isotope quantitation have shown great promise for the simultaneous and automated identification…
  3. We describe here a multiplexed protein quantitation strategy that provides relative and absolute measurements of proteins in complex mixtures. At the core of this methodology is a multiplexed set of isobaric reagents that yield amine-derivatized…
  4. Proteomic analysis is aimed at identifying a subset of proteins in a biomedical sample. In principle, this can be accomplished through two different routes. The first, and most common, approach is to break down the proteins into peptide segments of…
  5. The quantification of differences between two or more physiological states of a biological system is among the most important but also most challenging technical tasks in proteomics. In addition to the classical methods of differential protein gel…

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