GPCRs

In this group: 46 papers · 6 members

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Biological Sciences

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Chuong Nguyen added a document to this group

The second extracellular loop of GPCRs determines subtype-selectivity and controls efficacy as evidenced by loop exchange study at A2 adenosine receptors.

20th March

Timothy Craig added a document to this group

Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution.

22nd January

Timothy Craig added documents to this group

Co-evolving stability and conformational homogeneity of the human adenosine A2a receptor.

Evolution of three human GPCRs for higher expression and stability-Supporting Material

Evolution of three human GPCRs for higher expression and stability.

Practical Considerations of Membrane Protein Instability during Purification and Crystallisation

8th January, 2012

Timothy Craig added a document to this group

Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expression

2nd January, 2012

Timothy Craig added documents to this group

The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure.

Purified , refolded GPCRs as tools in drug discovery

FROM THE ANALYST ’ S COUCH Structural proteomics FROM THE ANALYST ’ S COUCH Market indicators

Structure-Based Identification of Binding Sites , Native Ligands and Potential Inhibitors for G-Protein Coupled Receptors

Structural Mimicry in G Protein-Coupled Receptors : Implications of the High-Resolution Structure of Rhodopsin for Structure-Function Analysis of Rhodopsin-Like Receptors

31st December, 2011

Timothy Craig added documents to this group

Recent advances in the production of proteins in insect and mammalian cells for structural biology

Lipid composition of Spodoptera frugiperda ( Sf9 ) and Trichoplusia ni ( Tn ) insect cells used for baculovirus infection

Overcoming the challenges of membrane protein crystallography

Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expression

Fluorescence-detection size-exclusion chromatography for precrystallization screening of integral membrane proteins.

23rd November, 2011

Created by Timothy Craig

6th November, 2011

About this group

Owned by Timothy Craig

Researcher (at a non-Academic Institution)

Biological Sciences

This group is for those interested in GPCRs ( G-protein coupled receptors). These transmembrane signaling proteins are responsible for regulating nearly any process you can think of. We would like to discuss and share information about ligand binding assays, expression constructs, cell based assays, and other types of experiments.

NAZANIN KERMANI

Matheus Garcia de Fragas

Ivan Rodriguez Torrecillas

cell based assay Class A Class B Class C g protein Galpha Gi GPCR GPCRs Gq lcp ligand binding assay ligands membrane protein receptor receptors Structure

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