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Papers in this group

  1. After several decades dominated by reductionist approaches in biology, researchers are returning to the study of complex biology with a litany of new and old techniques - this paradigm has been termed systems biology. Here we detail how systems…
  2. Stochastic switching is considered as a cost-saving strategy for adaptation to environmental challenges. We show here that stochastic switching of a monostable circuit can mediate the adaptation of the engineered OSU12-hisC Escherichia coli strain…
  3. Neurons are among the most highly polarized cell types in the body, and the polarization of axon and dendrites underlies the ability of neurons to integrate and transmit information in the brain. Significant progress has been made in the…
  4. Cellular regulation is believed to evolve in response to environmental variability. However, this has been difficult to test directly. Here, we show that a gene regulation system evolves to the optimal regulatory response when challenged with…

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