Papers in this group
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It is generally assumed that axons use action potentials (APs) to transmit information fast and reliably to synapses. Yet, the reliability of transmission along fibers below 0.5 microm diameter, such as cortical and cerebellar axons, is unknown.…
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We describe a mechanism for coincidence detection mediated by the interaction between backpropagating action potentials and EPSPs in neocortical pyramidal neurons. At distal dendritic locations, appropriately timed EPSPs or oscillations could…
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The detection and discrimination of temporal sequences is fundamental to brain function and underlies perception, cognition, and motor output. By applying patterned, two-photon glutamate uncaging, we found that single dendrites of cortical pyramidal…
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We analyze in this article the significance of the edge of chaos for real-time computations in neural microcircuit models consisting of spiking neurons and dynamic synapses. We find that the edge of chaos predicts quite well those values of circuit…
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The trajectory of the somatic membrane potential of a cortical neuron exactly reflects the computations performed on its afferent inputs. However, the spikes of such a neuron are a very low-dimensional and discrete projection of this continually…
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The development of cortical layers, areas and networks is mediated by a combination of factors that are present in the cortex and are influenced by thalamic input. Electrical activity of thalamocortical afferents has a progressive role in shaping…
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The cerebral cortex is pivotal in information processing and higher brain function and its laminar structure of six distinct layers, each in receipt of a different constellation of inputs, makes it important to identify connectivity patterns and…
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Synchronized firing of mitral cells (MCs) in the olfactory bulb (OB) has been hypothesized to help bind information together in olfactory cortex (OC). In this survey of synchronized firing by suspected MCs in awake, behaving vertebrates, we find the…
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In the cortex, synaptic latencies display small variations ( approximately 1-2 ms) that are generally considered to be negligible. We show here that the synaptic latency at monosynaptically connected pairs of L5 and CA3 pyramidal neurons is…
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In Pavlovian and instrumental conditioning, reward typically comes seconds after reward-triggering actions, creating an explanatory conundrum known as "distal reward problem": How does the brain know what firing patterns of what neurons are…
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A widely discussed hypothesis in neuroscience is that transiently active ensembles of neurons, known as "cell assemblies," underlie numerous operations of the brain, from encoding memories to reasoning. However, the mechanisms responsible for the…
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With deregulation and growth of the power industry, many power system elements such as generators, transmission lines, are driven to operate near their maximum capacity, especially those serving heavy load centres. Wide Area Controllers (WACs) using…
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I review a class of hybrid models of neurons that combine continuous spike-generation mechanisms and a discontinuous 'after-spike' reset of state variables. Unlike Hodgkin-Huxley-type conductance-based models, the hybrid spiking models have a few…
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We developed a quantitative description of the circuits formed in cat area 17 by estimating the "weight" of the projections between different neuronal types. To achieve this, we made three-dimensional reconstructions of 39 single neurons and…
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Layer 2/3 (L2/3) pyramidal cells receive excitatory afferent input both from neighbouring pyramidal cells and from cortical and subcortical regions. The efficacy of these excitatory synaptic inputs is modulated by spike timing-dependent plasticity…
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We show that the information carried by compound events in neural spike trains-patterns of spikes across time or across a population of cells-can be measured, independent of assumptions about what these patterns might represent. By comparing the…
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The resting brain recapitulates activity patterns that occurred during a recent experience, possibly to aid long-term memory formation. Surprisingly, corresponding brain activity also occurs before an event happens.
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Standard echo state networks (ESNs) are built from simple additive units with a sigmoid activation function. Here we investigate ESNs whose reservoir units are leaky integrator units. Units of this type have individual state dynamics, which can be…