Gerard van Westen, MSc
Hinxton, United Kingdom
Research field: Chemistry
Machine learning, statistical modeling, GPCRs
Publications
-
Journal Article (10)
-
Gerard J. P. van Westen, Alwin Hendriks, Jörg K. Wegner et al. (2013) Significantly Improved HIV Inhibitor Efficacy Prediction Employing Proteochemometric Models Generated From Antivirogram Data, 18. In PLoS Computational Biology 9 (2).Download HTML (188.09 KB)Download PDF (1.25 MB)
-
J. Robert Lane, Carmen Klein Herenbrink, Gerard J.P. Van Westen et al. (2012) A Novel Nonribose Agonist, LUF5834, Engages Residues That Are Distinct from Those of Adenosine-Like Ligands to Activate the Adenosine A2a Receptor, 475-487. In Molecular Pharmacology 81 (3).
-
Miriam C Peeters, Gerard J P van Westen, Dong Guo et al. (2011) GPCR structure and activation: an essential role for the first extracellular loop in activating the adenosine A2B receptor, 632-643. In The FASEB Journal 25 (2).
-
Gerard J P van Westen, Joerg K Wegner, Adriaan P Ijzerman et al. (2011) Proteochemometric Modeling as a Tool for Designing Selective Compounds and Extrapolating to Novel Targets, 16-30. In Medicinal Chemistry Communications 2 (1).
-
Gerard J. P. van Westen, Jörg K. Wegner, Peggy Geluykens et al. (2011) Which Compound to Select in Lead Optimization? Prospectively Validated Proteochemometric Models Guide Preclinical Development, e27518. In PLoS ONE 6 (11).Download PDF (572.16 KB)
-
Eelke Van der Horst, Julio E Peironcely, Gerard J P Van Westen et al. (2010) Chemogenomics Approaches for Receptor Deorphanization and Extensions of the Chemogenomics Concept to Phenotypic Space. In Current Topics in Medicinal Chemistry.
-
Miriam C Peeters, Gerard J P van Westen, Qilan Li et al. (2010) Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation., 42-35. In Trends in pharmacological sciences 32 (1).
-
Gerard J P van Westen, Jörg K Wegner, Andreas Bender et al. (2010) Mining protein dynamics from sets of crystal structures using "consensus structures", 742-752. In Protein Science 19 (4).
-
Munikumar R Doddareddy, Gerard J P van Westen, Eelke van der Horst et al. (2009) Chemogenomics: Looking at Biology through the Lens of Chemistry, 149-160. In Statistical Analysis and Data Mining.
-
Miriam C. Peeters, Qilan Li, Gerard J. P. van Westen et al. Three “hotspots” important for adenosine A2B receptor activation: a mutational analysis of transmembrane domains 4 and 5 and the second extracellular loop . In Purinergic Signalling.
-
Awards and Grants
-
Oct 2011First Prize Section Medicinal Chemistry of the Royal Dutch Chemistry Society at the FIGON DMD View website
-
Jun 2011Best Presentation by Junior Scientist (TI Pharma GPCR Forum) View website
-
Oct 2010Silver Poster Prize Section Medicinal Chemistry of Royal Dutch Chemistry Society View website
-
Oct 2010Bronze Prize National PhD Student Competition FIGON Days 2010 View website
-
Apr 2010LACDR PhD Student Competition First Prize View website
Biographical Information
I studied Biopharmaceutical Sciences at Leiden University from September 2001 until September 2007. In the final years I have done two major internships. The first one was within the LACDR on a biochemical project. The second one was something completely different on a computational project at Tibotec in Mechelen Belgium. It was here that I discovered the challenging side of computational research.
I did my PhD at the group of Medicinal Chemistry Leiden in close collaboration with Tibotec in the fall of 2007 until 2012. My project focused on the development of proteochemometric modeling which can map structure activity relations between a series of compounds and a series of proteins including pair specific interaction data.Developing this technique and characterizing its advantages and possible shortcomings is the aim of my work (a collaboration between Leiden University and Jansen Belgium)
Currently I started as a postdoc in the ChEMBL group (headed by John Overington) at the European Bioinformatics Institute. The project is a cooperation between the EBI and the group of Sthephen Cusack in Grenoble.
Please see my personal website (www.gjpvanwesten.nl) for further info, publications and reprint requests.
Specialties: In silico research, modeling, machine learning, proteochemometrics, chemogenomics, QSAR, computer aided drug design
I am always interested in collaborations, so don't hesitate to contact me.
I did my PhD at the group of Medicinal Chemistry Leiden in close collaboration with Tibotec in the fall of 2007 until 2012. My project focused on the development of proteochemometric modeling which can map structure activity relations between a series of compounds and a series of proteins including pair specific interaction data.Developing this technique and characterizing its advantages and possible shortcomings is the aim of my work (a collaboration between Leiden University and Jansen Belgium)
Currently I started as a postdoc in the ChEMBL group (headed by John Overington) at the European Bioinformatics Institute. The project is a cooperation between the EBI and the group of Sthephen Cusack in Grenoble.
Please see my personal website (www.gjpvanwesten.nl) for further info, publications and reprint requests.
Specialties: In silico research, modeling, machine learning, proteochemometrics, chemogenomics, QSAR, computer aided drug design
I am always interested in collaborations, so don't hesitate to contact me.
CV
Professional Experience
2012 - Present
Nov 2007 - Mar 2012
Education
Sep 2001 - Sep 2006
Leiden University
in Leiden, Netherlands
MSc
MSc
Consulting Services
Johnson & Johnson
Johnson & Johnson
Contact Information
| Webpage: | www.gjpvanwesten.nl |
Public Groups
Public groups Gerard is a member of
Public groups Gerard is following
- Not following any groups yet.
- Find new public groups.
Destinations
Sign up today - FREE
Mendeley saves you time finding and organizing research. Learn more