Dr. Michael Jeltsch's Publications

Pipsa Saharinen, Hanna Helotera, Juho Miettinen, Camilla Norrmen, Gabriela D'Amico, Michael Jeltsch, Tobias Langenberg, Wouter Vandevelde, Annelii Ny, Mieke Dewerchin, Peter Carmeliet, Kari Alitalo (2010) Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development., 875-80. In Genes & development 24 (9).

Denis Tvorogov, Andrey Anisimov, Wei Zheng, Veli-Matti Leppänen, Tuomas Tammela, Simonas Laurinavicius, Wolfgang Holnthoner, Hanna Heloterä, Tanja Holopainen, Michael Jeltsch, Nisse Kalkkinen, Hilkka Lankinen, Päivi M Ojala, Kari Alitalo (2010) Effective Suppression of Vascular Network Formation by Combination of Antibodies Blocking VEGFR Ligand Binding and Receptor Dimerization., 630-40. In Cancer cell 18 (6).

Veli-Matti Leppänen, Andrea E Prota, Michael Jeltsch, Andrey Anisimov, Nisse Kalkkinen, Tomas Strandin, Hilkka Lankinen, Adrian Goldman, Kurt Ballmer-Hofer, Kari Alitalo (2010) Structural determinants of growth factor binding and specificity by VEGF receptor 2., 2425-30. In Proceedings of the National Academy of Sciences of the United States of America 107 (6).

Veli-Matti Leppänen, Michael Jeltsch, Andrey Anisimov, Denis Tvorogov, Kukka Aho, Nisse Kalkkinen, Pyry Toivanen, Seppo Ylä-Herttuala, Kurt Ballmer-Hofer, Kari Alitalo (2010) Structural determinants of vascular endothelial growth factor-D - receptor binding and specificity.. In Blood.

Imke Albrecht, Lucie Kopfstein, Karin Strittmatter, Tibor Schomber, Annelie Falkevall, Carolina E Hagberg, Pascal Lorentz, Michael Jeltsch, Kari Alitalo, Ulf Eriksson, Gerhard Christofori, Kristian Pietras (2010) Suppressive effects of vascular endothelial growth factor-B on tumor growth in a mouse model of pancreatic neuroendocrine tumorigenesis., e14109. In PloS one 5 (11).

Maija Bry, Riikka Kivelä, Tanja Holopainen, Andrey Anisimov, Tuomas Tammela, Jarkko Soronen, Johanna Silvola, Antti Saraste, Michael Jeltsch, Petra Korpisalo, Peter Carmeliet, Karl B Lemström, Masabumi Shibuya, Seppo Ylä-Herttuala, Leena Alhonen, Eero Mervaala, Leif C Andersson, Juhani Knuuti, Kari Alitalo (2010) Vascular Endothelial Growth Factor-B Acts as a Coronary Growth Factor in Transgenic Rats Without Inducing Angiogenesis, Vascular Leak, or Inflammation., 1725-33. In Circulation 122 (17).

Andrey Anisimov, Annamari Alitalo, Petra Korpisalo, Jarkko Soronen, Seppo Kaijalainen, Veli-Matti Leppänen, Michael Jeltsch, Seppo Ylä-Herttuala, Kari Alitalo (2009) Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle., 1302-12. In Circulation research 104 (11).

Terhi Karpanen, Maija Bry, Hanna M Ollila, Tuulikki Seppa, Erkki Liimatta, Hanna Leskinen, Riikka Kivela, Teemu Helkamaa, Mari Merentie, Michael Jeltsch, Karri Paavonen, Leif C Andersson, Eero Mervaala, Ilmo E Hassinen, Seppo Yla, Matej Ores, Kari Alitalo (2008) Overexpression of Vascular Endothelial Growth Factor-B in Mouse Heart Alters Cardiac Lipid Metabolism and Induces Myocardial Hypertrophy, 1018-1026. In Circulation Research 103 (9).

Xuri Li, Marc Tjwa, Inge Van Hove, Berndt Enholm, Elke Neven, Karri Paavonen, Michael Jeltsch, Toni Diez Juan, Richard E Sievers, Emmanuel Chorianopoulos, Hiromichi Wada, Maarten Vanwildemeersch, Agnes Noel, Jean-Michel Foidart, Matthew L Springer, Georges von Degenfeld, Mieke Dewerchin, Helen M Blau, Kari Alitalo, Ulf Eriksson, Peter Carmeliet, Lieve Moons (2008) Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium., 1614-20. In Arteriosclerosis, thrombosis, and vascular biology 28 (9).

Caroline A. Heckman, Tanja Holopainen, Maria Wirzenius, Salla Keskitalo, Michael Jeltsch, Seppo Yla-Herttuala, Stephen R. Wedge, Juliane M. Jurgensmeier, Kari Alitalo (2008) The Tyrosine Kinase Inhibitor Cediranib Blocks Ligand-Induced Vascular Endothelial Growth Factor Receptor-3 Activity and Lymphangiogenesis, 4754-4762. In Cancer Research 68 (14).

Tuomas Tammela, Yulong He, Johannes Lyytikkä, Michael Jeltsch, Johanna Markkanen, Katri Pajusola, Seppo Ylä-Herttuala, Kari Alitalo (2007) Distinct architecture of lymphatic vessels induced by chimeric vascular endothelial growth factor-C/vascular endothelial growth factor heparin-binding domain fusion proteins, 1468-1475. In Circulation Research.

S Keskitalo, T Tammela, J Lyytikka, T Karpanen, M Jeltsch, J Markkanen, S Yla-Herttuala, K Alitalo (2007) Enhanced Capillary Formation Stimulated by a Chimeric Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor-C Silk Domain Fusion Protein, 1460-1467. In Circulation Research 100 (10).

Terhi Karpanen, Caroline A Heckman, Salla Keskitalo, Michael Jeltsch, Hanna Ollila, Gera Neufeld, Luca Tamagnone, Kari Alitalo (2006) Functional interaction of VEGF-C and VEGF-D with neuropilin receptors, 1462-1472. In The FASEB Journal 20 (9).

M Jeltsch, T Karpanen, T Strandin, K Aho, H Lankinen, K Alitalo (2006) Vascular Endothelial Growth Factor (VEGF)/VEGF-C Mosaic Molecules Reveal Specificity Determinants and Feature Novel Receptor Binding Patterns, 12187-12195. In Journal of Biological Chemistry 281 (17).

Rainer Krebs, Jussi M Tikkanen, Antti I Nykänen, Jeanette Wood, Michael Jeltsch, Seppo Ylä-Herttuala, Petri K Koskinen, Karl B Lemström (2005) Dual Role of Vascular Endothelial Growth Factor in Experimental Obliterative Bronchiolitis, 1421-1429. In American Journal of Respiratory and Critical Care Medicine 171 (12).

Peter Baluk, Tuomas Tammela, Erin Ator, Natalya Lyubynska, Marc G Achen, Daniel J Hicklin, Michael Jeltsch, Tatiana V Petrova, Bronislaw Pytowski, Steven A Stacker, David G Jackson, Kari Alitalo, Donald M McDonald (2005) Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation, 247-257. In Journal of Clinical Investigation 115 (2).

Yulong He, Iiro Rajantie, Katri Pajusola, Michael Jeltsch, Tanja Holopainen, Seppo Yla-Herttuala, Thomas Harding, Karin Jooss, Takashi Takahashi, Kari Alitalo (2005) Vascular Endothelial Cell Growth Factor Receptor 3–Mediated Activation of Lymphatic Endothelium Is Crucial for Tumor Cell Entry and Spread via Lymphatic Vessels, 4739-4746. In Cancer Research 65 (11).

Marika J Karkkainen, Paula Haiko, Kirsi Sainio, Juha Partanen, Jussi Taipale, Tatiana V Petrova, Michael Jeltsch, David G Jackson, Marja Talikka, Heikki Rauvala, Christer Betsholtz, Kari Alitalo (2004) Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins, 74-80. In Nature Immunology 5 (1).

Michael Jeltsch, Tuomas Tammela, Kari Alitalo, Jörg Wilting (2003) Genesis and pathogenesis of lymphatic vessels, 69-84. In Cell and Tissue Research 314 (1).

Tanja Veikkola, Marja Lohela, Kristian Ikenberg, Taija Mäkinen, Thomas Korff, Anne Saaristo, Tatania Petrova, Michael Jeltsch, Hellmut G Augustin, Kari Alitalo (2003) Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function., 2006-13. In The FASEB Journal 17 (14).

Holger Gerhardt, Matthew Golding, Marcus Fruttiger, Christiana Ruhrberg, Andrea Lundkvist, Alexandra Abramsson, Michael Jeltsch, Christopher Mitchell, Kari Alitalo, David Shima, Christer Betsholtz (2003) VEGF guides angiogenic sprouting utilizing endothelial tip cell fillopodia, 1163-1178. In The Journal of Cell Biology 161 (6).

Anne Saaristo, Tanja Veikkola, Berndt Enholm, Maija Hytönen, Johanna Arola, Katri Pajusola, Päivi Turunen, Michael Jeltsch, Marika J Karkkainen, Dontscho Kerjaschki, Hansruedi Bueler, Kari Alitalo, Seppo Yla (2002) Adenoviral VEGF-C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes, 1041-1049. In The FASEB Journal 16 (9).

B Enholm, T Karpanen, M Jeltsch, H Kubo, F Stenback, R Prevo, D G Jackson, S Yla-Herttuala, K Alitalo (2001) Adenoviral expression of vascular endothelial growth factor-C induces lymphangiogenesis in the skin, 623-629. In Circulation Research.

T Veikkola, L Jussila, T Makinen, T Karpanen, M Jeltsch, T V Petrova, H Kubo, G Thurston, D M McDonald, M G Achen, S A Stacker, K Alitalo (2001) Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice., 1223-31. In The EMBO Journal 20 (6).

S J Mandriota, L Jussila, M Jeltsch, A Compagni, D Baetens, R Prevo, S Banerji, J Huarte, R Montesano, D G Jackson, L Orci, K Alitalo, G Christofori, M S Pepper (2001) Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis., 672-82. In The EMBO journal 20 (4).

M O Hiltunen, M Laitinen, M P Turunen, M Jeltsch, J Hartikainen, T T Rissanen, J Laukkanen, M Niemi, M Kossila, T P Häkkinen, A Kivelä, B Enholm, H Mansukoski, A M Turunen, K Alitalo, S Ylä-Herttuala (2000) Intravascular adenovirus-mediated VEGF-C gene transfer reduces neointima formation in balloon-denuded rabbit aorta, 2262-2268. In Circulation.

B Olofsson, M Jeltsch, U Eriksson, K Alitalo (1999) Current biology of VEGF-B and VEGF-C., 528-35. In Current opinion in biotechnology 10 (6).

Michael S Pepper, Stefano J Mandriota, Michael Jeltsch, Vijay Kumar, Kari Alitalo (1998) Vascular endothelial growth factor (VEGF)-C synergizes with basic fibroblast growth factor and VEGF in the induction of angiogenesis in vitro and alters endothelial cell extracellular proteolytic activity, 439-452. In Journal of Cellular Physiology 177 (May).

B Olofsson, E Korpelainen, M S Pepper, S J Mandriota, K Aase, V Kumar, Y Gunji, M M Jeltsch, M Shibuya, K Alitalo, U Eriksson (1998) Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells, 11709-11714. In Proceedings of the National Academy of Sciences 95 (20).

M G Achen, M Jeltsch, E Kukk, T Mäkinen, A Vitali, A F Wilks, K Alitalo, S A Stacker (1998) Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4), 548-553. In Proceedings of the National Academy of Sciences 95 (2).

Dmitri Chilov, Eola Kukk, Suvi Taira, Michael Jeltsch, Jaakko Kaukonen, Aarno Palotie, Vladimir Joukov, Kari Alitalo (1997) Genomic Organization of Human and Mouse Genes for Vascular Endothelial Growth Factor C, 25176 -25183. In The Journal of Biological Chemistry 272 (40).

M Jeltsch, A Kaipainen, V Joukov, X Meng, M Lakso, H Rauvala, M Swartz, D Fukumura, R K Jain, K Alitalo (1997) Hyperplasia of lymphatic vessels in VEGF-C transgenic mice, 1423-1425. In Science.

Vladimir Joukov, Tarja Sorsa, Vijay Kumar, Michael Jeltsch, Lena Claesson-Welsh, Yihai Cao, Olli Saksela, Nisse Kalkkinen, Kari Alitalo (1997) Proteolytic processing regulates receptor specificity and activity of VEGF-C, 3898-3911. In The EMBO Journal 16 (13).

V Joukov, A Kaipainen, M Jeltsch, K Pajusola, B Olofsson, V Kumar, U Eriksson, K Alitalo (1997) Vascular Endothelial Growth Factors VEGF-B and VEGF-C, 211-215. In Journal of Cellular Physiology.

S J Oh, M M Jeltsch, R Birkenhager, J E Mccarthy, H A Weich, B Christ, K Alitalo, J Wilting (1997) VEGF and VEGF-C: specific induction of angiogenesis and lymphangiogenesis in the differentiated avian chorioallantoic membrane, 96-109. In Developmental Biology.

E Kukk, A Lymboussaki, S Taira, A Kaipainen, M Jeltsch, V Joukov, K Alitalo (1996) VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development, 3829-3837. In Development.