Why most published research findings are false.

There is increasing concern that most current published research findings are false. The probability that a research claim is true may depend on study power and bias, the number of other studies on the same question, and, importantly, the ratio of…

There is increasing concern that most current published research findings are false. The probability that a research claim is true may depend on study power and bias, the number of other studies on the same question, and, importantly, the ratio of…

Copyright: copyright 2007 Goodman and Greenland. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the…

There is increasing concern that most current published research findings are false. The probability that a research claim is true may depend on study power and bias, the number of other studies on the same question, and, importantly, the ratio of…

A recent article in this journal (Ioannidis JP (2005) Why most published research findings are false. PLoS Med 2: e124) argued that more than half of published research findings in the medical literature are false. In this commentary, we examine the…

While the authors agree with John Ioannidis that "most research findings are false," here they show that replication of research findings enhances the positive predictive value of research findings being true.

Positive biomedical observations are more often published than those reporting no effect, initial observations are often refuted or attenuated by subsequent determine whether newspapers preferentially report on initial findings and whether they also…

Positive biomedical observations are more often published than those reporting no effect, initial observations are often refuted or attenuated by subsequent determine whether newspapers preferentially report on initial findings and whether they also…

The article presents a discussion on the four major mistakes leaders make in managing change in the organization, adapted from the book "Beyond the Wall of Resistance: Why 70% of All Changes Still Fail-and What You Can Do About It."

Background: Published false positive research findings are a major problem in the process of scientific discovery. There is a high rate of lack of replication of results in clinical research in general, multiple sclerosis research being no…