Production of the antimalarial drug precursor artemisinic acid in engineered yeast.
by
Dae-Kyun Ro,
Eric M Paradise,
Mario Ouellet,
Karl J Fisher,
Karyn L Newman,
…
John M Ndungu,
Kimberly A Ho,
Rachel A Eachus,
Timothy S Ham,
James Kirby,
Michelle C Y Chang,
Sydnor T Withers,
Yoichiro Shiba,
Richmond Sarpong,
Jay D Keasling
show all authors
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Jorge F S Ferreira in Journal of Agricultural and Food Chemistry (2007)Artemisia annua became a valuable agricultural crop after the World Health Organization recommended artemisinin as a component of ACT (artemisinin-combination based therapies) for malaria in 2001. A cloned, greenhouse-grown, A. annua (Artemis)…Save reference to library · Related research 2 readers
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J Han, J G Lee, S S Min, S H Park, C K Angerhofer, G A Cordell, in Journal of Natural Products (2001)Artemisinic acid (2) was modified through allylic oxidation at C-3 or conjugate addition at C-13 to afford 12 methyl artemisinate derivatives (4-15). Photooxidation of the derivatives yielded eight new artemisinin analogues, including…Save reference to library · Related research 5 readers
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Hanbang Zhang, Ellen M Howard, Paul D Roepe in The Journal of Biological Chemistry (2002)Mutations in the novel membrane protein Pfcrt were recently found to be essential for chloroquine resistance (CQR) in Plasmodium falciparum, the parasite responsible for most lethal human malaria (Fidock, D. A., Nomura, T., Talley, A. K., Cooper, R.…Save reference to library · Related research 13 readers
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